Texas voters overwhelmingly approved a constitutional amendment in 2007 establishing the Cancer Prevention and Research Institute of Texas (CPRIT) and authorizing the state to issue $3 billion in bonds to fund groundbreaking cancer research and prevention programs and services in Texas. CPRIT’s goal is to expedite innovation and commercialization in the area of cancer research and to enhance access to evidence-based prevention programs and services throughout the state. CPRIT accepts applications and awards grants for a wide variety of cancer-related research and for the delivery of cancer prevention programs and services by public and private entities located in Texas. More information about CPRIT and the funded proposals is available at its website, www.cprit.state.tx.us.

Here is who got funding!

January 20, 2010 CPRIT Research Awards

High Impact/High Risk: Short term projects that are developmental or exploratory in nature targeting new avenues of cancer research that, if successful, will contribute to major new insights into the etiology, diagnosis, treatment, or prevention of cancers.

Total monies awarded: $ 2,596,950
Recipients:
Baylor College of Medicine
Baylor University
InGeneron, Inc.
Rice University
Texas A&M University
The University of Texas at Austin
The University of Texas Health Science Center at Houston
The University of Texas M. D. Anderson Cancer Center
The University of Texas Southwestern Medical Center at Dallas

Individual Investigator: Innovative research proposals directed by a single investigator addressing critically important questions that will significantly advance knowledge of the causes, preventions and/or treatment of cancer.

Total monies awarded: $ 56,311,597
Recipients:
Baylor College of Medicine
Rice University
Texas A&M University System Health Science Center
Texas Tech University Health Sciences Center
The Methodist Hospital Research Institute
The University of Texas at Austin
The University of Texas at Dallas
The University of Texas Health Science Center at Houston
The University of Texas Health Science Center at San Antonio
The University of Texas M. D. Anderson Cancer Center
The University of Texas Southwestern Medical Center at Dallas
Visualase, Inc.

Recruitment (First Time, Tenure Track, Rising Stars and Superstars) Awards tailored to the career stage of the targeted recruits for relocation to Texas.

Total monies awarded: $ 2,000,000
Recipients:
The University of Texas Health Science Center San Antonio

Cancer Research Institute Activities

Eating a pomegranate everyday can help prevent breast cancer, new research reveals. American scientists are saying pomegranates contain chemical agents known as phytochemicals, which play an important role in the prevention of breast cancer.

Scientists at the City of Hope Cancer Research and Treatment Center in Duarte, California, have discovered that the fruit contains a large amount of the phytochemical called ellagitannins. The phytochemical has an inhibitory effect on the enzyme aromatase, which plays a pivotal role in making the hormone oestrogen, which in turn leads to most of the cases of breast cancer. Meanwhile, many patients who suffer from the breast cancer take medicines which are actually aromatase inhibitors.

The research which was published in the journal ‘Cancer Prevention Research’ highlights the fact that laboratory experiments that were carried out took into account around 10 compounds from the pomegranate and their effects were subsequently tested. Among the compounds which were taken into consideration, urolithin B was seen to be the most effective in preventing breast cancer.

However, researcher Shiuan Chen, who was intrinsically involved with the research, emphasized that the compounds did not turn out to be as effective as actual drugs due to which researchers have warned the patients against using the fruit as a replacement of the aromatase inhibitor medicines. At the same time, it has been implied that the results are not conclusive and further tests need to be carried out in order to confirm the findings. However, the findings are being considered to be significant as it might herald a new era in breast cancer treatment.

Read more: Pomegranates and Cancer.

Meanwhile, doctors are warning cancer patients not to put their hopes too high regarding miracle recoveries through prayer and meditation, after the head of Australia’s Catholics confidently stated that prayer could cure malignancy.

Defending the Vatican’s attribution of miracles to saint-in-waiting Mary MacKillop, Cardinal George Pell yesterday said “obviously” prayer could cure cancer and there were “a number of examples in the books”.

But cancer experts say prayer should not take priority over conventional treatments.

David Goldstein, senior staff specialist in the department of medical oncology at Sydney’s Prince of Wales Hospital, said spontaneous remission of cancer happened in about one or two cases in every 1000.

“It would be a brave person that used prayer instead of conventional treatment for a curable cancer — it’s a complementary practice,” Dr Goldstein said.

Prayer shares some similarities with meditation, which has been shown to lower blood pressure. Dr Goldstein said it was “impossible to dissect out” whether improvements seen in patients who pray were due to these and other explainable phenomena, such as the fact people who attended church also tended to live more healthily.

Previous studies into the effect of prayer have produced mixed results. A review of 10 previous trials by the international Cochrane Collaboration found when patients were prayed for by others, they enjoyed no significant improvement in outcomes compared to others who were not prayed for.

Cancer Council Australia chief executive Ian Olver said medicine and prayer were “not incompatible” and people with faith should consider the possibility that God was working through the patient’s doctors.

Professor Olver recently conducted a study measuring the spiritual wellbeing of 509 cancer patients who, unknown to them, were being prayed for, and compared them to 490 for whom the trial authors did not arrange prayers. The study found a small but significant improvement in spiritual wellbeing, but did not measure any health changes.

Cancer survivor Ian Gawler, who founded the Gawler Foundation to promote self-help cancer techniques, said there was increasing evidence prayer had a positive effect. “When I was at my sickest, there were quite large groups of people that were praying for me, and I took great comfort from that,” he said.

Harvard researchers are finding an intriguing link between coffee and the prevention of an aggressive type of prostate cancer.

Prostate cancer kills 27,000 men annually. So this research comparing the history of thousands and thousands of men raises the possibility of a simple and effective prevention in this deadly disease.

The researchers discovered that men who drank six or more cups of coffee a day had a 60 percent lower risk developing the advanced form of the disease when compared to men who drank no coffee at all.

Even men who drank just one to three cups are showed a lower risk, about 20 percent, of developing the aggressive cancer.

Prostate cancer specialist Dr. Ihor Sawczuk, of Hackensack University Medical Center, says the researchers were not exactly sure what it is about the coffee that might affect the cancers. But he says it’s too early to recommend boosting coffee drinking to men, although one cup of coffee might be helpful.

“I think those that don’t drink coffee should consider perhaps a cup a day may help build up their immune system,” he said. “I think what we need to remember is there may be more to this story.”

And finding out more details will be the next job for researchers. Because one study is not enough for scientists, the findings will need to be confirmed.

But if coffee helps prevention, it’s a bonus for those who already drink it and a simple benefit for those who don’t.

Prostate cancer survivor Richard Williamson has made some already-proven lifestyle changes for his recovery. He’s lost 25 pounds, walks two miles daily and, because he doesn’t eat enough fruits and vegetables, now frequents a health food store near his home to get his vegetables in a drink he likes.

“I do my walk and then I stop there,” he said. “I do that three or four times a week.”

Other proven prevention habits include:

“Decrease the total amount of fat, taking good fat, for example, the omega-3,” Dr. Sawczuk said. “Tomatoes have lycopene, especially the skin of tomatoes. These are good substancse to ingest. Soy products, apples, perhaps even a glass of red wine.”

And now, maybe a cup of coffee or two. One way coffee might be working is that it’s known to help the body use insulin. And high insulin has already been proven to increase risk of prostate cancer.

Neale had also been recuperating from injuries sustained after being hit by an automobile while driving his Vespa scooter in Toronto on Aug. 3, 2007.

His friends and musicians were totally shocked by the news, particularly since many of them thought that he was finished with the worst part of his illness and was in a recovery phase.

“That guy just exuded what it is to be a really cool, down to earth, just amazing individual,” Toronto hip-hop MC Kardinal Offishall told CP backstage at the SOCAN awards on Monday. “Wow. Canada really lost something special.”

Family members and some of his friends were at his side as he died.

“Through all these challenges, Haydain’s sense of humour and love of music were ever-present,” his wife Michaela said.

He consistently brightened the room with his singing and his dazzling smile. His playful presence and rich voice will be missed by us all. Jacksoul was to release “SOULmate,” on Dec. 1 with 10 new tracks.

The first single, “Lonesome Highway,” was co-produced and co-written by Neale, and touches on his recovery, supported by his wife, daughter Yasmin and numerous others. Former Treble Charger frontman Greg Nori considered Neale a close friend since the two men worked side by side in studio space at the Sony offices.

“This guy was an extremely, extremely generous person,” Nori said backstage at the SOCAN event. “(He) was always 120 per cent to me, as an individual, he really was. I always had a really great friendship with him and we had a great respect for each other.

“I never saw the guy get mad. He only had positive energy about him. That’s my recollection of him. Never, ever did I see any kind of jealousy out of him, or negativity.”

Kardinal Offishall, likewise, said Neale was a special human being.

“People who never had the chance to meet him were able to see that not just through his music, but just in how he carried himself, just the type of dude that he was,” said the rapper, who says he had checked in on Neale’s status by sending a text message to a mutual friend just days before his death.

Jacksoul’s previous hits include “Can’t Stop” and “Still Believe in Love.” Neale was known for his soulful, elastic croon, for a voice that was faithfully smooth but organic and expressive.

“Hopefully his music will live on,” said Hedley guitarist Dave Rosin. That’s all any artist can hope. … It’s a sad thing.”

Nori, meanwhile, praised Neale’s integrity, versatility and commitment to his artistic ideals.

“I think he was always tackling something that wasn’t the flavour of the moment,” Nori said. “I think it was always a struggle to him because it wasn’t flavour of the moment, and it didn’t sell as much.

“He always had the ability to go do that if he wanted to, but he stuck to his guns and stayed with what he knew was in his heart, and I commend him for that.”

An interment with a private family gathering will take place later this week.

Although scientists are reluctant to endorse green tea as a cancer prevention method, evidence continues to grow regarding the chemically complex drink’s potential benefits – including results of a new randomized, controlled trial by researchers at University of Texas M. D. Anderson Cancer Center, which suggest it had some inhibiting effect in patients with a pre-malignant condition known as oral leukoplakia.

As reported in a report published online Nov 5 by Cancer Prevention Research(1), a team headed by Vassiliki Papadimitrakopoulo, MD, professor of medicine in M.D. Anderson’s Department of Thoracic/Head and Neck Medical Oncology, tested green tea extract taken orally for three months by 41 patients diagnosed with oral leukoplakia and therefore at high risk of developing oral cancer.

The patients were divided into cohorts taking either placebo or one of three different doses of green tea extract 500 mg/m2, 750 mg/m2 or 1,000 mg/m2 [mg/m2 refers to milligrams per meter squared of body mass – calculated by a formula using height and weight to reflect a person’s relative size].

The researchers assessed clinical response in oral pre-malignant lesions and found:

• 58.8% of patients at the highest doses displayed clinical response,

• Compared with 18.2% among those taking placebo.

They also observed:

• A trend toward improved histology [cell & tissue integrity],

• And a trend towards improvement in a handful of biomarkers that may be important in predicting cancer development.

Patients were followed for 27.5 months and at the end of the study period, 15 developed oral cancer.

• Although there was no difference in oral cancer development overall between those who took green tea and those who did not,

• Patients who presented with mild to moderate dysplasia [abnormal cell growth] had a longer time to develop oral cancer if they took green tea extract.

Although encouraged by the results, Dr. Papadimitrakopoulo cautioned against any recommendations that green tea could definitely prevent cancer.

“This is a phase II study with a very limited number of patients who took what would be the equivalent of drinking eight to 10 cups of green tea every single day,” she said. “We cannot with certainty claim prevention benefits from a trial this size.”

Dong Shin, MD, (professor of hematology and medical oncology at Emory School of Medicine, and a Cancer Prevention Research editorial board member) agreed, but said this trial is certainly a step in the right direction. “A clinical trial with a natural compound is no easy task, and these researchers have accomplished that,” Dr. Shin stated in a companion article commenting on the trial(2). “The lack of toxicity is also important because often when you give supplements at higher doses than what would occur naturally, you induce nausea and vomiting. That did not happen in this trial.”

Neither researcher had a reason why patients concerned about cancer should not drink green tea, but they cautioned against relying on the beverage to definitively reduce their risk of cancer.

“The goal of this kind of research is to determine whether or not these supplements have long-term prevention effects,” said Dr. Papadimitrakopoulou. “More research – including studies in which individuals at high risk are exposed to these supplements for longer time period – is still needed to answer that sort of question.”

Tobacco

This is the single largest preventable cause of cancer in the world. It causes over 80% of all lung cancer deaths, and 30% of all cancer deaths in the third world. This includes deaths from cancer of the oral cavity, larynx, oesophagus and stomach. A comprehensive program which would include a stop to tobacco advertising, increased taxation on tobacco products, and stop smoking programs can greatly reduce the use of tobacco in many countries. The World Health Organization Framework Convention on Tobacco Control adopted measures in May 2003, aims to curb tobacco-related deaths and disease. We are looking for updates on their progress.

Diet

Changes in diet is another critical action to take to prevent and control cancer. There are know links between obesity and many types of cancer such as oesophagus, colorectum, breast, endometrium and kidney. Diets high in fruits and vegetables have a preventative effect against a great number of cancers. On the other hand, consumption of red and preserved meat is connected with an increased risk of colorectal cancer.Healthy eating habits which ameliorate the development of diet-related cancers have the added benefit of lowering the potential for cardiovascular disease.

Exercise

Regular physical exercise along with a healthy body weight and healthy diet, will greatly reduce the chances of cancer. National policies and programs have been implemented in some countries which raise awareness and reduce exposure to cancer risk factors. To ensure that citizens are provided with the information and the tools they need to adopt healthy lifestyles governments may play a large role.

Preventing Disease

Infectious agents are responsible for almost one quarter of cancer deaths in the third world and 1 in 20 in industrialized countries. Viral hepatitis B and C can cause liver cancer; human papilloma virus infection can cause cancer of the cervix; the bacterium Helicobacter pylori can greatly increase the risk of stomach cancer. In some countries the parasitic infection schistosomiasis increases the risk of bladder cancer and in other countries the liver fluke increases the risk of cholangiocarcinoma to do with the bile ducts system. Preventive measures include vaccination and prevention of infection and infestation.

Radiation

Exposure to radiation is well known to cause some cancers. Solar ultraviolet radiation can raise the risk of all types of skin cancer. Avoiding excessive exposure, use of sunscreen and protective clothing are important preventive activities.

Asbestos

On the subject of home and workplace safety, asbestos must be looked at because it can cause lung cancer. Also aniline dyes have been linked to bladder cancer. Benzene has been linked to leukemia. The prevention of certain occupational and environmental exposure to these and other chemicals are important steps to take in preventing cancer.

Smile For Cancer Prevention video

This is a very challenging process for most women.

Many women may suffer depression when they experience iatrogenic hair loss caused by chemotherapy. Partial or radical mastectomies are, of course, more devastating to women.

It requires tremendous emotional strength to go through these processes. One aspect that is distressing is a woman’s appearance and the impact on her body image.

When a woman is diagnosed with breast cancer, it can be a life changing experience. She may discover a lump in her breast while involved in routine activities.
After the lump is removed and a biopsy is performed the doctor may give a diagnosis of breast cancer, Stage I or Stage II breast cancer.

The first thing that a woman might do in these circumstances is to look for other opinions and alternative methods.

Some doctors may suggest the immediate removal of the breast followed by reconstructive surgery.

In any case, the focus of her life has now shifted completed to the cancer and issues to do with surgery and all the implications that a mastectomy may have on her sense of self.

Obviously a woman’s life is more valuable than her breasts. The patient may know this very well but it is very difficult to stop identifying oneself as a woman with certain body. They can’t imagine life without their breasts.

Typically a woman at this point will agree to any needed surgery. After the surgery it can be extremely shocking to wake up and not feel or see their breasts. There is a state of cognitive dissonance.

Breasts are one symbol of femininity. It is a very delicate matter for a person. She may feel insecure or depressed at this point and start worrying about their future relationships with men.

Implants may help but the truth is that they do not feel or look the same. Injections are needed frequently to make the implants expand. Life has changed forever and therapy is indicated to help deal with the emotional difficulties and with self acceptance.

The struggle to reconcile herself with her breasts being removed is only one difficulty she has to face.

Chemotherapy treatment, which usually follows the mastectomy, can be pretty rough and then their is thinning hair – another blow to the body image.

While brushing her hair she may notice it start to fall out.

Some women simply shave their heads so that they don’t have to go through the gradual process of hair loss. Although this is also a trying aspect of breast cancer treatment it is not as devastating as the loss of her breasts.

A woman will often begin to wear a wig or a head scarf or other head covering.

There are a number of emotional and physical challenges of this process. The most important thing is to have the love and support of family and friends.

If breast cancer is treated well, and there is a great deal of support from others as well as self-acceptance, there is nothing stopping a woman from moving on to a new chapter in her life.

The endorsement from Food and Drug Administration advisers moves the Cervarix vaccine closer to the U.S. market to compete with Merck & Co Inc’s Gardasil shot.

The panel is set to vote later on Wednesday on whether to allow Merck to widen its potential market for Gardasil by promoting the vaccine to men and boys as young as 9 for prevention of genital warts.

Both vaccines are designed to prevent infection from the human papillomavirus (HPV), a virus that causes cervical cancer and genital warts.

These included cancers of the esophagus, stomach, colon, lungs, pancreas, liver and prostate.

When the researchers looked at individual types of alcohol, though, only beer and “spirits” — and not wine — were linked to elevated cancer risks.

In general, the odds increased in tandem with the men’s lifetime alcohol intake, according to findings published in the Cancer Prevention and Detection. With several cancers, men who drank at least once a day tended to have higher risks than those who drank on a regular, but less-than-daily, basis.

When it came to esophageal cancer, for instance, men who had a drink one to six times per week had an 83 per cent higher risk than teetotalers and less-frequent drinkers, while daily drinkers had a three-fold higher risk.

In addition, when the researchers looked only at daily drinkers, the risks generally increased with the number of years the men had been drinking daily.

“Our results show that the heaviest consumers over the lifetime had the biggest increases in the risks of multiple sites of cancer,” researcher Dr. Andrea Benedetti told Reuters.

Many studies have suggested that moderate drinking — usually defined as no more than a drink or two per day — can be a healthy habit, particularly when it comes to heart disease risk.

But the current study suggested that even such moderate drinking levels are linked to higher risks of certain cancers, at least when the alcohol of choice is beer or liquor.

The question of whether moderate drinkers should cut down, however, cannot be answered by a single study.

The Science Behind Beer and Health
October 2006 (Medialink) – Who knew that beer may help reduce the risk of heart disease and certain other chronic diseases related to aging? According to a professor of medicine and public health at the Boston University School of Medicine, it may. Dr. Curtis Ellison spoke at a conference on a panel called, “Beer: To Your Health!,” held by the Center for Food, Nutrition and Agriculture Policy at the University of Maryland-College Park. This conference reviewed the science on health benefits of moderate beer and alcohol consumption and the challenges of communicating a balanced message to the public.

Brewed from barley, malt and other grains, some studies suggest that beer may have heart-healthy benefits and that older adults who consume moderate amounts of alcohol may have a lower risk of heart disease, stroke, diabetes, dementia, osteoporosis – and maybe even obesity.

The key is moderation. U.S. dietary guidelines define “moderation” as one drink per day for women, and two for men. Experts say that for those who choose to drink, alcohol should be consumed with food – and that the total number of alcoholic drinks should not be averaged out for the week. That means people should not save their ‘drink a day’ all week and then have seven drinks on Saturday night.