Sandy Hutchens Cancer Prevention

Chinese Medicine Drug May Treat Cancer

A promising cancer drug, first discovered in a mushroom commonly used in Chinese medicine, could be made more effective thanks to researchers who have discovered how the drug works. The research is funded by the Biotechnology and Biological Sciences Research Council and was carried out at The University of Nottingham.

In research to be published in the Journal of Biological Chemistry, Dr Cornelia de Moor of The University of Nottingham and her team have investigated a drug called cordycepin, which was originally extracted from a rare kind of wild mushroom called cordyceps and is now prepared from a cultivated form.

Dr de Moor said: “Our discovery will open up the possibility of investigating the range of different cancers that could be treated with cordycepin. We have also developed a very effective method that can be used to test new, more efficient or more stable versions of the drug in the Petri dish. This is a great advantage as it will allow us to rule out any non-runners before anyone considers testing them in animals.”

Cordyceps is a strange parasitic mushroom that grows on caterpillars (see image). Properties attributed to cordyceps mushroom in Chinese medicine made it interesting to investigate and it has been studied for some time. In fact, the first scientific publication on cordycepin was in 1950. The problem was that although cordycepin was a promising drug, it was quickly degraded in the body. It can now be given with another drug to help combat this, but the side effects of the second drug are a limit to its potential use.

Dr de Moor continued: “Because of technical obstacles and people moving on to other subjects, it’s taken a long time to figure out exactly how cordycepin works on cells. With this knowledge, it will be possible to predict what types of cancers might be sensitive and what other cancer drugs it may effectively combine with. It could also lay the groundwork for the design of new cancer drugs that work on the same principle.”

The team has observed two effects on the cells: at a low dose cordycepin inhibits the uncontrolled growth and division of the cells and at high doses it stops cells from sticking together, which also inhibits growth. Both of these effects probably have the same underlying mechanism, which is that cordycepin interferes with how cells make proteins. At low doses cordycepin interferes with the production of mRNA, the molecule that gives instructions on how to assemble a protein. And at higher doses it has a direct impact on the making of proteins.

Learn about Herbs – Rhodiola and Cordyceps (video)

Having sex at an early age can double the risk of developing cervical cancer, a study of 20,000 women suggests.

The investigation into why poorer women have a higher risk of the disease found they tended to have sex about four years earlier than more affluent women.

Previously, it had been thought the disparity was the result of low screening uptake in poorer areas.

The International Agency for Research on Cancer findings are published in the British Journal of Cancer.

Although the difference in cervical cancer incidence between rich and poor – across the world – had been noted for many years, it was not clear why this is the case.

Especially as rates of infection with human papillomavirus (HPV) – the sexually transmitted infection linked with the vast majority of cervical cancers – seemed to be similar across all groups.

The study confirmed that the higher rates of cervical cancer were not linked to higher HPV levels.

But what it did reveal is that the two-fold increased risk was largely explained by women from poorer backgrounds starting to have sex at a younger age.

The age at which a woman had her first baby was also an important factor.

Screening was found to have some effect on the level of risk.

But the number of sexual partners a woman has and smoking did not account for any of the difference.

Teresa Heinz, the wife of 2004 Democratic presidential nominee Sen. John Kerry, disclosed today that she is battling breast cancer in an editorial in the Pittsburgh Post-Gazette.

“I was diagnosed and treated for stage one cancer (two different types) in both breasts. The cancer was detected at an early stage thanks to a mammogram and the work of a remarkable physician who insisted on investigating beyond what the mammogram could show,” she writes, “I have had two operations and my prognosis for a full recovery is good.”

Heinz editorializes that women should ignore new guidelines from the U.S. Preventive Services Task Force that stated women at average risk don’t need regular screenings and that mammograms in older women can be reduced to every two years, versus previous annual guidelines.

She opines that the task force is “predisposed to choose numbers over people.”

“Our busy lives are full of those. What we need are more reasons to keep those appointments, more support of the value of prevention and refinement of diagnostic procedures, and more choices.”

The Obama administration has distanced itself from the task force’s recommendations amid backlash from women’s and medical groups. The Department of Health and Human Services did not endorse the findings.

The Associated Press reported that Heinz was treated by a surgeon at Massachusetts General Hospital that she had recommended to Elizabeth Edwards, the wife of Kerry’s 2004 running mate John Edwards, who was diagnosed with breast cancer shortly after their failed presidential bid.

Heinz told AP she has not spoken with Elizabeth Edwards since her own diagnosis.